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Clinical Use

Which patients are appropriate for Defined Sleep?

A structure/function supplement that supports restorative sleep — with clear guidance on where it fits, and where it does not.

Appropriate patient profiles

  • Adults reporting poor sleep quality or non-restorative sleep, including those whose wearable data shows low deep/REM proportion
  • Patients who decline prescription hypnotics, or for whom sedating medication is undesirable (fall risk, next-day grogginess, occupational alertness requirements)
  • Melatonin non-responders and patients reporting melatonin grogginess
  • Shift workers — the most responsive subgroup in our clinical trial
  • Patients seeking a non-habit-forming nightly option

When to refer or evaluate further

Defined Sleep supports sleep; it is not a treatment for sleep disorders. Consider evaluation or referral for suspected obstructive sleep apnea, parasomnias, restless legs syndrome, or when insomnia is secondary to a psychiatric or medical condition requiring management.

What Defined Sleep is not

  • Not a hypnotic and not sedating — it will not “knock a patient out”
  • Not habit-forming
  • Not indicated to diagnose, treat, cure, or prevent any disease

Review drug interactions Combining with CBT-I

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Published study (JCSM) · ClinicalTrials.gov NCT05233761 · Ask our science & medical team

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.