Leadership

Extensive clinical expertise is foundational to everything we do. Defined Sleep's leadership and advisory boards for Science, Medical, and Strategy provide us with unparalleled guidance in providing integrity and transparency to consumers and healthcare providers.

Founder / CEO / CSO

Paul Muchowski, Ph.D. 

  • Ph.D. Biological Structure University of Washington

  • Post-doctoral training Max Planck Institute for Biochemistry

  • Professor University of Washington and University of California San Francisco

  • Neuroscience drug discovery (Soteria Therapeutics and Teva Pharmaceuticals)

  • Chair Emeritus of the Scientific Advisory Committee for the National Cannabis Industry Association

  • Published >60 highly cited research studies

  • Holds numerous patents

Science Advisory Board

Nephi Stella, Ph.D.

  • Professor University of Washington

  • Thought leader in cannabinoid science (>60 cannabinoid publications)

  • Discovered second endogenous cannabinoid (2-AG)

  • Founder: Stella Therapeutics


David Housman, Ph.D.

  • Professor Massachusetts Institute of Technology
  • Founder: Genzyme Genetics (Sanofi), Integrated Genetics, Variagenics, Somatix Therapy Corp.
  • Member, National Academy of Sciences and Institute of Medicine


Anne Young, M.D./Ph.D.

  • Professor Emeritus Harvard / Massachusetts General Hospital
  • Chair Emeritus, Harvard Neurology
  • Former President, Society for Neuroscience & American Neurological Association
  • Member, Institute of Medicine


John Clark, Ph.D.

  • Professor University of Washington

  • Thought leader in aging on the eye

  • Former President, Association for Research in Vision and Ophthalmology




Adriano Aguzzi, M.D. / Ph.D.

  • Professor of neuropathology and director of the Institute of Neuropathology University of Zurich
  • Expert in the pathogenesis of prion diseases and neurodegenerative diseases
  • Founding Director of the Swiss National Reference Center for Prion Diseases.
  • Founder Mabylon

Medical Advisory Board

Elise Grenier, M.D.

Owner/Medical Director of Office MD and the G Spa in San Francisco

  • B.A. Integrative Biology University of California Berkeley
  • M.S. Molecular Biology and Biochemistry University of California, Berkeley
  • M.D. Finch University of Health Sciences/The Chicago Medical School
  • Internship/Residency University of California, San Francisco in Family Medicine at San Francisco General Hospital
  • Board Certified American Board of Family Medicine (ABFM) and American Academy of Aesthetics Medicine (AAAM)


Karen Muchowski, M.D.
Physician Palomar Health Medical Group


  • B.S. Physiology University of California Davis, Summa Cum Laude
  • M.D. University of California Davis
  • Internship/Residency Oregon Health Sciences University Family Medicine
  • Board Certified American Board of Family Medicine (ABFM)







Thuan Dang, M.D.
Physician Shriners Children’s Chicago


  • Physician Shriners Children's Chicago
  • B.S. University of Michigan
  • M.P.H. University of Michigan
  • M.D. Michigan State University College of Human Medicine
  • Residency University of Chicago
  • Sleep Medicine Fellowship Northwestern McGaw
  • Board Certified American Board of Psychiatry and Neurology (ABPN) and Sleep Medicine




Strategic Advisory Board

Donald Plumley

Strategic Advisor

  • 30+ years business advisor and executive

  • Sage Partners, Elanex, Polycold, Bowne Global Solutions, Fresh Victor, Honeywell

  • M.B.A. International Business University of California Los Angeles

  • B.S. Physiology University of California Davis





Gary Seelhorst

Strategic Advisor

  • 20+ years corporate strategy and business development in biotech, medtech & big pharma

  • Eli Lily, Pfizer, Imprimis Pharmaceuticals, Flora, Justice Grown

  • B.S. Biochemistry, B.A. Psychology University of California San Diego

  • M.S. Biology Indiana University

  • M.B.A. Finance University of Michigan


Frederick Felman

Strategic Advisor

  • 30+ marketing executive & business advisor
  • Sage Partners,Thompson Reuters, ZoneLabs, Accenture
  • B.S. Business Administration University of Southern California