Physician Indication & Safety Information
Recommend Defined Sleep with Confidence
Increased Shift Worker deep and REM sleep. Our groundbreaking clinical sleep trial showed that shift workers had the best response to Defined Sleep’s formula, enjoying higher rates of deep and REM sleep. Only a good night’s sleep can combat what’s known as “sleep debt”, a deficit in the Deep and REM sleep phases which are crucial for human well-being.
Safety
- No adverse events were reported in the clinical trial.
- Non-sedating.
- No effects on heart rate or heart rate variability.
- No risk for dependency.
- Contains no THC, is non-psychoactive and non-intoxicating. Will not cause fall risk for elderly. Safe option for those required to undergo workplace drug testing.
Defined Sleep is safe to use on a daily basis for the vast majority of patients. However, it should not be taken by women who are pregnant. Additionally, a small number of prescription medications are contraindicated with CBD, and therefore it is important to check what medicines your patients are taking before recommending Defined Sleep. To determine if any prescription drugs your patients are taking are contraindicated with CBD, please check: https://www.webmd.com/interaction-checker/default.htm.
Moreover, we recommend that patients do not take Defined Sleep if they are taking any of the following drugs: clarithromycin, itraconazole, ketoconazole, posaconazole, voriconazole, ritonavir, cyclosporine, rifampin, theophylline, tizanidine, lamotrigine, morphine, lorazepam, diazepam, clobazam, stiripentol, valproate, everolimus, sirolimus or tacrolimus.
The recommended dose is to take 300 mg (two gel caps) one hour before going to bed. Higher doses (up to 600 mg) are well tolerated and may be more effective for some patients who suffer from extreme insomnia.
Defined Sleep: Key Differentiators from Over-the-counter (OTC) Sleep Aids and Prescription Sleep Medicines
Prescription Drug or OTC Sleep Aid | Mechanism of Action | Sedative | Effects on Deep and REM Sleep | Risk of Dependency and Misuse | Untoward Adverse Effects |
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Defined Sleep | OTC Sleep Aid | Multiple | No | Increases1 | No | No |
OTC Sleep Aid | Anti-histamine | Yes | Decreases2 | No | Yes | |
Doxylamine (Unisom) | OTC Sleep Aid | Anti-histamine | Yes | No Effect3 | No | Yes |
OTC Sleep Aid | Melatonin Receptor Agonist | Yes | May Decrease4 | No | Yes | |
OTC Sleep Aid | GABA Receptor- Agonist | Yes | Not Determined | Yes | Yes | |
OTC Sleep Aid | GABA Receptor- Agonist | Yes | Not Determined | Yes | Yes | |
Zolpidem (Ambien) | Drug | GABA Receptor-Benzodiazepene Agonist | Yes | Decreases4 | Yes | Yes |
Eszopiclone (Lunesta) | Drug | GABA Receptor-Benzodiazepene Agonist | Yes | No Effect5 | Yes | Yes |
Zaleplon (Sonata) | Drug | GABA Receptor-Benzodiazepene Agonist | Yes | Decreases6 | Yes | Yes |
Temazepam (Restoril) | Drug | Benzodiazepene | Yes | Yes | Yes | |
Doxepin (Silenor) | Drug | Anti-depressant | Yes | Decreases8 | Yes | Yes |
Ramelteon (Rozerem) | Drug | Melatonin Receptor Agonist | Yes | Decreases9 | Yes | Yes |
Drug | Anti-depressant | Yes | Decreases10 | Yes | Yes |