Paul Muchowski, Ph.D.
Founder & CEO/CSO, Defined Sleep
Paul Muchowski, Ph.D. is the Founder and CEO/CSO of Defined Sleep. A former professor at UCSF and the University of Washington, he brings decades of neuroscience drug-discovery expertise to clinically validated sleep science.
He has published more than 60 peer-reviewed studies and led the research behind Defined Sleep's landmark clinical trial in the Journal of Clinical Sleep Medicine.
Credentials & expertise
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Education
Ph.D., Biological Structure — University of Washington
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Post-doctoral training
Max Planck Institute for Biochemistry
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Academic affiliations
Former Professor, University of Washington and University of California, San Francisco
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Industry experience
Neuroscience drug discovery — Soteria Therapeutics and Teva Pharmaceuticals
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Research focus
Neurodegeneration, sleep science, and clinically validated cannabinoid therapeutics
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Publications
Published 60+ highly cited peer-reviewed research studies; holds numerous patents
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Leadership
Chair Emeritus, Scientific Advisory Committee — National Cannabis Industry Association
Published research
Explore his broader publication record on PubMed
As featured in
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GQ
Defined Sleep featured in an expert guide to evening routines for better sleep.
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GQ
Quoted on melatonin and sleep science: "Melatonin — not a sleep aid."
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CBS Atlanta — Focus Atlanta
Paul Muchowski discusses sleep science and Defined Sleep on Focus Atlanta.
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Brain Health Podcast
Episode 38 — Dr. Nick Nissen interviews Paul Muchowski on the value of deep sleep.
Recent articles by Paul
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REM vs Deep Sleep: What Matters More?
Defined Sleep Blog · Oct 30, 2026 -
Melatonin Alternatives: Neurochemical Insights and Options
Defined Sleep Blog · Oct 30, 2026 -
Herbal Sleep Teas: Which Ingredients Have Proven Efficacy?
Defined Sleep Blog · Oct 30, 2026 -
Copy of Awake at 3 a.m. again? Here is what I tell my patients (Dr. Grenier blog draft)
Defined Sleep Blog · Oct 30, 2026 -
Every Dog Has Its Dose: What Repeated CBD Dosing Teaches Us
Defined Sleep Blog · Oct 09, 2026 -
How Non-Drug Sleep Solutions Compare to Over-The-Counter (OTC) Sleep Aids
Defined Sleep Blog · Sep 24, 2026